Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) jẹ iṣesi awọ to ṣọwọn; ni 90 % ti awọn ọran, o ni ibatan si lilo oogun. Acute generalized exanthematous pustulosis ni a ṣe apejuwe nipasẹ awọn eruptions awọ ara lojiji tí ó hàn ní àárín ọjọ marun lẹ́yìn tí a ti bẹ̀rẹ̀ oogun kan. Awọn eruptions wọ̀nyí jẹ́ pustules, iyẹn ni, àwọn àkúnya pupa kékeré tàbí àkúnya pupa tí ó ní àwọn kurukuru tàbí purulent (pus). Àwọn àkúnya awọ ara máa ń bọ́ lára ní àárín ọjọ 1‑3 lẹ́yin tí a dáwọ́ oogun dúró.
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Awọn egbo ti o gbooro, pẹlu erythema ati pustules, farahan lojiji.
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ReferencesAcute generalized exanthematous pustulosis (AGEP) jẹ́ àìlera awọ ara tí a mọ̀ọ́mọ̀ nípa àwọn àkúnya kékeré tí ó ń bọ́ lórí àwọ̀ pupa. Ó sábà máa ṣẹlẹ̀ nígbà tí ènìyàn bá ń gba àwọn òògùn kan, bíi àwọn egboogi, tí ó sì ń tan kárí ara. Lẹ́yìn tí a dáwọ́ òògùn tó ń fa àìlera náà dúró, àwọn ààmì aisan máa ń lọ́ọ́ padà ní ọ̀sẹ̀ méjì, tí ó sábà máa ń yọ̀rí sí ìdínkù àwọ̀ ara díẹ̀. Bó tilẹ̀ jẹ́ pé ó máa ń jẹ́ àìlera tó kéré tí kò ní ìpẹ̀yà tó pọ̀, ṣùgbọ́n ní àwọn ọ̀ràn tó nira, ó lè kópa pẹ̀lú àìlera míì bí Stevens-Johnson syndrome tàbí toxic epidermal necrolysis. Ìtọ́jú pàtàkì ni ìtọ́jú àtìlẹ́yìn, àti pé àkókò tó péye fún ìdánimọ̀ tó péye ti àìlera náà máa ń dá àbájáde tó dára sílẹ̀.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Ọkunrin ẹni ọdun 76 kan wa si yara pajawiri nitori awọ ara rẹ ti yipada ni ọjọ meji sẹhin. Awọn dokita ri awọn abulẹ pupa ati awọn agbegbe ti a gbe soke lori ẹhin rẹ ati awọn apá ati awọn ẹsẹ. Bi akoko ti n lọ, awọn abulẹ wọnyi darapọ, o si ni idagbasoke pimple-bi awọn bumps ni awọn agbegbe pupa. Awọn idanwo fihan iye sẹẹli ẹjẹ funfun ti o ga pẹlu ọpọlọpọ iru ti a npe ni neutrophils, ati awọn ipele C-reactive protein ti o pọ si.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
