Acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) jẹ iṣesi awọ to ṣọwọn pe ni 90% awọn ọran ni ibatan si iṣakoso oogun. Acute generalized exanthematous pustulosis jẹ ijuwe nipasẹ awọn eruptions awọ ara lojiji ti o han ni apapọ ọjọ marun lẹhin ti oogun kan ti bẹrẹ. Awọn eruptions wọnyi jẹ pustules, ie kekere pupa pupa tabi eruption pupa ti awọ ara ti o ni awọn kurukuru tabi purulent (pus). Awọn egbo awọ ara nigbagbogbo yanju laarin awọn ọjọ 1-3 ti didaduro oogun ti o ṣẹ.
☆ Ninu awọn abajade 2022 Stiftung Warentest lati Jẹmánì, itẹlọrun alabara pẹlu ModelDerm jẹ kekere diẹ ju pẹlu awọn ijumọsọrọ telemedicine isanwo.
Awọn egbo ti o gbooro pẹlu erythema ati pustules farahan lojiji.
References
Acute generalized exanthematous pustulosis (AGEP) jẹ iṣesi awọ ara ti a samisi nipasẹ kekere, awọn bumps-pupọ lori ipilẹ awọ ara pupa. O maa n ṣẹlẹ nigbati ẹnikan ba mu awọn oogun kan, bi awọn egboogi, ti o si yara tan kaakiri ara. Lẹhin didaduro oogun ti o nfa, awọn aami aisan maa n lọ laarin ọsẹ meji, nigbagbogbo nlọ diẹ ninu sisọ awọ ara silẹ. Botilẹjẹpe igbagbogbo kii ṣe pataki ati ni opin si awọ ara, awọn ọran ti o nira le ṣe apejọ papọ pẹlu awọn aati awọ pataki miiran bi Stevens-Johnson syndrome tabi toxic epidermal necrolysis. Itọju jẹ itọju atilẹyin akọkọ, ati asọtẹlẹ fun ipinnu pipe ti arun na nigbagbogbo dara julọ.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Ọkunrin ẹni ọdun 76 kan wa si yara pajawiri nitori awọ ara rẹ ti yipada ni ọjọ meji sẹhin. Awọn dokita ri awọn abulẹ pupa ati awọn agbegbe ti a gbe soke lori ẹhin rẹ ati awọn apá ati awọn ẹsẹ. Bi akoko ti n lọ, awọn abulẹ wọnyi darapọ, o si ni idagbasoke pimple-bi awọn bumps ni awọn agbegbe pupa. Awọn idanwo fihan iye sẹẹli ẹjẹ funfun ti o ga pẹlu ọpọlọpọ iru ti a npe ni neutrophils, ati awọn ipele C-reactive protein ti o pọ si.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
